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Pesticidas formamidina: acciones similares a las de la octopamina en una luciérnaga
Science (New York, N.Y.)
|April 4, 1980
Resumen
Los pesticidas formamidina, como el clordimeformo, hacen que los órganos luminosos de las luciérnagas brillen. Este efecto, bloqueado por la ciproheptadina, sugiere una interacción con los sistemas de neurotransmisores de la octopamina, lo que podría explicar la acción de los pesticidas.
Área de la Ciencia:
- Toxicología de los insectos.
- La neurobiología es la neurobiología.
- Mecanismos de acción de los pesticidas.
Sus antecedentes:
- Los pesticidas formamidina, incluido el clordimeformo, son conocidos por sus propiedades pesticidas.
- La luciérnaga Photinus pyralis L. posee un órgano luminoso que puede ser inducido a brillar.
- La octopamina es un presunto neurotransmisor en el órgano luminoso de las luciérnagas.
Objetivo del estudio:
- Para investigar el efecto de los pesticidas formamidina en la bioluminiscencia de las luciérnagas.
- Para dilucidar el mecanismo subyacente al brillo inducido por los pesticidas.
- Explorar el papel potencial de los sistemas octopaminérgicos en la acción de los plaguicidas.
Principales métodos:
- Aplicación tópica de monodemethyl chlordimeform a las luciérnagas.
- Administración de ciproheptadina para bloquear el brillo inducido.
- Observación y comparación de la intensidad del brillo.
Principales resultados:
- El clordimeforme y sus metabolitos inducen brillantes luces en el órgano luminoso de las luciérnagas.
- El monodemetilclordimeformo es eficaz en dosis muy bajas (5 ng/insecto).
- La ciproheptadina bloquea significativamente los brillos inducidos tanto por el monodemetilclordimeformo como por la octopamina.
Conclusiones:
- La respuesta del órgano luminoso a las formamidinas es postsináptica, probablemente involucrando receptores unidos a la membrana.
- Los hallazgos sugieren que los pesticidas de formamidina pueden ejercer sus efectos mediante la interacción con los sistemas octopaminérgicos.
- Esta interacción podría ser la base de las propiedades pesticidas y pesticidas observadas de las formamidinas.
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