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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

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Deconstruir la vía del erizo en el desarrollo y las enfermedades.

Leni Jacob1, Lawrence Lum

  • 1Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Science (New York, N.Y.)
|October 6, 2007
PubMed
Resumen

La vía de señalización Hedgehog (Hh) regula el desarrollo celular y el equilibrio del tejido. Las interrupciones en esta vía crucial están relacionadas con defectos de nacimiento humanos y varios tipos de cáncer.

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Área de la Ciencia:

  • Biología del desarrollo Biología del desarrollo.
  • La señalización celular de las células.
  • Biología Molecular Biología Molecular

Sus antecedentes:

  • La familia de proteínas del erizo (Hh) es vital para la determinación del destino celular en los animales.
  • La señalización Hh controla el desarrollo embrionario y el mantenimiento de los tejidos.
  • La distribución de la proteína Hh dependiente de la dosis dicta el destino de la célula.

Objetivo del estudio:

  • Aclarar el papel de la señalización del erizo en el desarrollo de metazoos y la homeostasis.
  • Para resaltar la importancia de la regulación de la vía Hh en la salud humana y las enfermedades.

Principales métodos:

  • Utilizó estudios genéticos en organismos modelo como Drosophila y ratones.
  • Se analizaron los mecanismos moleculares de la acción dosis-dependiente de la proteína Hh.
  • Investigó las consecuencias de la desregulación de la vía Hh.

Principales resultados:

  • La señalización Hh es un regulador maestro del destino celular a través de los metazoos.
  • El desarrollo embrionario y la homeostasis de los tejidos dependen de Hh.
  • La señalización aberrante Hh está implicada en las malformaciones congénitas humanas y el cáncer.

Conclusiones:

  • La vía del erizo es fundamental para el desarrollo normal y la función del tejido.
  • Comprender la señalización Hh es fundamental para abordar las enfermedades humanas relacionadas con su corrupción.