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Updated: Jul 5, 2026

Harvesting and Cryo-cooling Crystals of Membrane Proteins Grown in Lipidic Mesophases for Structure Determination by Macromolecular Crystallography
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Published on: September 2, 2012

La estructura cristalina del receptor adrenérgico beta2 humano acoplado a la proteína G

Søren G F Rasmussen1, Hee-Jung Choi, Daniel M Rosenbaum

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, Palo Alto, California 94305, USA.

Nature
|October 24, 2007
PubMed
Resumen

Los investigadores determinaron la estructura del beta2 adrenoceptor humano (beta2AR), un receptor clave acoplado a la proteína G (GPCR), revelando información sobre su inestabilidad y actividad basal. Esto hace avanzar la biología estructural de GPCR.

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G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
G Protein-coupled Receptors01:15

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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
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GPCRs are also called heptahelical, 7TM, or...