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Selective Tracing of Auditory Fibers in the Avian Embryonic Vestibulocochlear Nerve
Published on: March 18, 2013
El origen de la actividad espontánea en el sistema auditivo en desarrollo.
Nicolas X Tritsch1, Eunyoung Yi, Jonathan E Gale
1The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.
Nature
|November 2, 2007
Resumen
Las células de apoyo en el desarrollo de la cóclea liberan ATP, iniciando la actividad del nervio auditivo antes de la audición. Esta señalización mediada por ATP refina los mapas tonotópicos del cerebro y cesa al inicio de la audición.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Desarrollo del sistema de auditoría Desarrollo del sistema de auditoría
- La señalización celular.
Sus antecedentes:
- La actividad espontánea es crucial para el desarrollo del sistema auditivo, la supervivencia neuronal y el refinamiento del mapa tonotópico.
- Los mecanismos que inician el disparo del nervio auditivo antes de la aparición del sonido siguen sin estar claros.
Objetivo del estudio:
- Aclarar los mecanismos responsables de la actividad espontánea del nervio auditivo en la cóclea en desarrollo.
- Para investigar el papel de las células de apoyo en la iniciación de esta actividad neuronal pre-audición.
Principales métodos:
- Utilizó un modelo de coclea de rata en desarrollo.
- Investigó la liberación de ATP de las células de apoyo.
- Examinó los efectos del ATP en las células ciliadas internas y las neuronas auditivas primarias.
Principales resultados:
- Las células de apoyo en la cóclea en desarrollo liberan espontáneamente trifosfato de adenosina (ATP).
- El ATP desencadena la despolarización de las células ciliadas internas, lo que lleva a la liberación de glutamato.
- Este proceso inicia potenciales de acción en las neuronas auditivas primarias, sincronizando la salida de las células ciliadas internas vecinas.
- La señalización espontánea dependiente del ATP disminuye después de que comienza la audición.
Conclusiones:
- Las células de apoyo inician la actividad eléctrica espontánea en los nervios auditivos antes de la audición.
- La señalización mediada por ATP juega un papel crítico en el refinamiento de los mapas tonotópicos.
- Las células periféricas no sensoriales son esenciales para el desarrollo de las vías auditivas centrales.
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