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Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
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Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions

Published on: August 2, 2018

La proteasa 1 específica de SUMO es esencial para la estabilización de HIF1alpha durante la hipoxia

Jinke Cheng1, Xunlei Kang, Sui Zhang

  • 1Department of Cardiology, The University of Texas MD Anderson Cancer Center, The University of Texas, Houston Health Science Center, Houston, TX 77030, USA.

Cell
|November 6, 2007
PubMed
Resumen

La proteasa 1 específica de Sentrin/SUMO (SENP1) es crucial para el desarrollo fetal. La pérdida de SENP1 causa anemia al interrumpir la estabilidad del factor 1alfa inducible por hipoxia (HIF1alpha), lo que afecta la producción de eritropoyetina.

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