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Anticancerígenos y antimicrobianos agentes metalofarmacéuticos basados en el paladio, el oro y la plata
Sriparna Ray1, Renu Mohan, Jay K Singh
1Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India.
Journal of the American Chemical Society
|November 9, 2007
Resumen
Se sintetizaron nuevos complejos de paladio, oro y plata con carbenos N-heterocíclicos. Los complejos de paladio muestran una potente actividad anticancerígena, superando al cisplatino, mientras que los complejos de oro y plata exhiben propiedades antimicrobianas.
Área de la Ciencia:
- Química organometálica Química orgánica de los metales.
- Química Medicinal La Química Medicinal es el campo de la Química Medicinal.
- Ciencia de los materiales Ciencia de los materiales.
Sus antecedentes:
- Los carbenos N-heterocíclicos (NHC) son ligandos versátiles en la química de la coordinación.
- Los complejos metálicos de los NHC se han mostrado prometedores en aplicaciones biomédicas.
Objetivo del estudio:
- Para sintetizar y caracterizar nuevos complejos de paladio, oro y plata con un ligando 1-benzil-3-tert-butilimidazol-2-ilideno.
- Evaluar las actividades anticancerígenas y antimicrobianas de estos complejos metálicos.
Principales métodos:
- Síntesis de complejos metálicos mediante reacción directa o transmitación.
- Elucidación estructural mediante difracción de rayos X.
- Evaluación in vitro de las actividades antiproliferativas y antimicrobianas.
Principales resultados:
- Dos complejos de paladio (1a, 1b), un complejo de oro (1c) y un complejo de plata (1d) fueron sintetizados con éxito y caracterizados estructuralmente.
- El complejo de Palladium 1b demostró una actividad antiproliferativa significativa contra las líneas celulares de cáncer de cuello uterino, mama y colon, que excede a la del cisplatino.
- El complejo 1b indujo la detención del ciclo celular G2 y la muerte celular programada a través de una vía dependiente de p53.
- El complejo de oro 1c y el complejo de plata 1d exhibieron actividad antimicrobiana contra Bacillus subtilis, siendo 1c dos veces más potente que 1d.
Conclusiones:
- Los complejos de paladio sintetizados exhiben potentes propiedades anticancerígenas, lo que justifica una mayor investigación para la terapia del cáncer.
- Los complejos de oro y plata muestran una actividad antimicrobiana prometedora, lo que sugiere aplicaciones potenciales en la lucha contra las infecciones bacterianas.
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