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A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1
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Papel esencial de una guanina en el sitio activo en la catálisis de la ribozima glmS

Daniel J Klein1, Michael D Been, Adrian R Ferré-D'Amaré

  • 1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA.

Journal of the American Chemical Society
|November 10, 2007
PubMed
Resumen

La ribozima glmS utiliza glucosamina-6-fosfato para la catálisis. Una mutación clave de la guanina desactiva esta función de la ribozima glmS, mostrando que una interacción específica de la nucleobasa es vital para la activación de la coenzima.

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