LIMP-2 es un receptor para la orientación lisosomal independiente de la manosa-6-fosfato de la

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David Reczek1, Michael Schwake, Jenny Schröder

  • 1Genzyme Corporation, 1 Mountain Road, Framingham, MA 01701, USA. david.reczek@genzyme.com

Cell
|November 21, 2007
PubMed
Resumen

La proteína de membrana integral lisosomal 2 (LIMP-2) actúa como un receptor específico para la beta-glucocerebrosidasa, independiente de la vía de la manosa-6-fosfato. La deficiencia de LIMP-2 causa una mala clasificación y secreción de beta-glucocerebrosidasa, lo que afecta a la investigación de la enfermedad de Gaucher.

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