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Entosis: es un mundo donde la célula se come a la célula
1Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Rutgers University, 679 Hoes Lane, Piscataway, NJ 08854, USA. ewhite@cabm.rutgers.edu
Cell
|November 30, 2007
Resumen
Los investigadores descubrieron un nuevo proceso de muerte celular llamado entosis en células mamarias separadas de la matriz extracelular. Esta vía de muerte celular, junto con la apoptosis, puede ayudar a suprimir los tumores al eliminar las células cancerosas.
Área de la Ciencia:
- Biología celular Biología celular.
- Investigación de Investigación del Cáncer.
- Mecanismos de muerte celular Mecanismos de muerte celular
Sus antecedentes:
- Las células epiteliales normalmente se adhieren a la matriz extracelular (ECM) para la supervivencia.
- El desprendimiento del ECM es un paso crítico en la progresión del cáncer epitelial.
- La apoptosis es una conocida vía de muerte celular programada involucrada en la supresión de tumores.
Objetivo del estudio:
- Para describir una vía de muerte celular no apoptótica recientemente identificada, entosis.
- Investigar el papel de la entosis en las células epiteliales mamarias en el desprendimiento del ECM.
- Explorar la contribución potencial de la entosis a la supresión del tumor.
Principales métodos:
- Observación de las células epiteliales mamarias después del desprendimiento de la MEC.
- Caracterización de una nueva vía de muerte celular distinta de la apoptosis.
Principales resultados:
- Una nueva vía de muerte celular, denominada entosis, fue identificada en células epiteliales mamarias separadas.
- La entosis representa una forma no apoptótica de muerte celular.
Conclusiones:
- La entosis, una nueva vía de muerte celular, puede desempeñar un papel en la eliminación de las células cancerosas separadas.
- La entosis, junto con la apoptosis, podría funcionar como un mecanismo supresor de tumores mediante la eliminación de células potencialmente cancerosas.
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