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Un proceso de muerte celular no apoptótica, entosis, que ocurre por invasión de células en células
Michael Overholtzer1, Arnaud A Mailleux, Ghassan Mouneimne
1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Cell
|November 30, 2007
Resumen
Las células epiteliales separadas de la matriz se someten a un nuevo proceso de muerte celular llamado entosis, en el que una célula invade a otra. Este fenómeno de célula en célula puede ser un mecanismo de supresión tumoral.
Área de la Ciencia:
- Biología celular Biología celular.
- Investigación del cáncer Investigación del cáncer.
- Citología citología citología.
Sus antecedentes:
- Las células epiteliales normalmente requieren la fijación de la matriz extracelular (ECM) para sobrevivir, previniendo el anoikis (una forma de apoptosis).
- El desprendimiento del ECM desencadena las vías de muerte celular en las células epiteliales.
Objetivo del estudio:
- Para describir un nuevo programa de muerte celular no apoptótica en células separadas de la matriz.
- Investigar el mecanismo detrás de la característica de "célula en célula" observada en los cánceres humanos.
Principales métodos:
- Observación de los procesos de internalización y degradación celular.
- Análisis del papel de las uniones de adherens y el compromiso de la integrina en la formación de células dentro de células.
Principales resultados:
- Identificó un nuevo proceso de muerte celular llamado entosis, en el que una célula viva invade y es internalizada por una célula vecina.
- Se demostró que las células internalizadas se degradan por los lisosomas o se liberan.
- Se presentaron pruebas que vinculan la entosis a la característica citológica "célula en célula" en los cánceres humanos.
Conclusiones:
- La entosis es un mecanismo de muerte celular no apoptótica para las células separadas de la matriz.
- La entosis es impulsada por las fuerzas de compactación de la formación de uniones de adherens sin compromiso de integrina.
- La entosis puede funcionar como un mecanismo intrínseco de supresión tumoral.
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