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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
Published on: June 16, 2011
La coevolución con los virus impulsa la evolución de las tasas de mutación bacteriana
Csaba Pal1, María D Maciá, Antonio Oliver
1Department of Zoology, University of Oxford, Oxford OX1 3PS, UK. angus.buckling@zoo.ox.ac.uk
Nature
|December 7, 2007
Resumen
Los bacteriófagos, o fagos, pueden conducir a las bacterias a evolucionar tasas de mutación más altas. Esta adaptación bacteriana, impulsada por la coevolución con los fagos, puede proporcionar una ventaja en su carrera armamentista evolutiva.
Área de la Ciencia:
- Biología evolutiva Biología evolutiva.
- Genética microbiana Genética microbiana.
- Interacciones entre bacteriófagos y bacterias.
Sus antecedentes:
- Las bacterias con altas tasas de mutación (mutadores) son comunes en diversos entornos e infecciones.
- Las altas tasas de mutación pueden mejorar la capacidad de adaptación, pero el riesgo de acumular mutaciones dañinas.
- Las presiones de selección que cambian rápidamente, como la coevolución de los parásitos, pueden mantener altas tasas de mutación.
Objetivo del estudio:
- Investigar si la coevolución con parásitos virales (fagos) impulsa la evolución de las tasas de mutación bacteriana.
- Determinar el impacto de la coevolución fago-bacteriana en las tasas de mutación bacteriana en poblaciones de laboratorio.
Principales métodos:
- Experimento de evolución de laboratorio utilizando poblaciones de Pseudomonas fluorescens.
- Coevolución con bacteriófagos (fagos) bajo condiciones controladas.
- Medición de las tasas de mutación e identificación de mutaciones en genes de reparación de desajustes.
Principales resultados:
- El 25% de las poblaciones con coevolución de fagos mostraron aumentos de 10 a 100 veces en las tasas de mutación dentro de 200 generaciones.
- No se observaron cambios significativos en la tasa de mutación en poblaciones que evolucionan sin fagos.
- Las poblaciones bacterianas mutantes demostraron una mayor probabilidad de llevar a las poblaciones de fagos a la extinción.
Conclusiones:
- La coevolución con bacteriófagos puede aumentar significativamente las tasas de mutación bacteriana.
- Las bacterias mutantes exhiben una ventaja contra los fagos en la carrera armamentista coevolucionaria.
- Es probable que los bacteriófagos jueguen un papel crucial en la configuración de la evolución de la tasa de mutación bacteriana.
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