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Redirigiendo los pasos de ciclización de la poliquetida sintasa fúngica

Suzanne M Ma1, Jixun Zhan, Xinkai Xie

  • 1Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, USA.

Journal of the American Chemical Society
|December 13, 2007
PubMed
Resumen

Los investigadores redirigieron las etapas de ciclización de la poliquetida sintasa fúngica (PKS) mediante la alteración de los dominios de la tioesterasa/claisen ciclasa (TE/CLC). Esto permitió la síntesis de nuevos policetidos y demostró el potencial para combinar componentes de PKS fúngicos y bacterianos.

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