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Videos de Conceptos Relacionados

Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
Diffusion01:12

Diffusion

Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
Diffusion01:21

Diffusion

Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting their diffusion into...
Membrane Fluidity01:26

Membrane Fluidity

Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Membrane Fluidity01:23

Membrane Fluidity

Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.Fatty acids tails of phospholipids can be either saturated or...

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Updated: Jul 9, 2026

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
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Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes

Published on: July 19, 2022

Difusión lateral en las membranas lipídicas a través de flujos colectivos.

Emma Falck1, Tomasz Róg, Mikko Karttunen

  • 1Laboratory of Physics and Helsinki Institute of Physics, Helsinki University of Technology, Finland.

Journal of the American Chemical Society
|December 15, 2007
PubMed
Resumen

La dinámica de las membranas celulares es poco conocida. Las simulaciones atómicas revelan que los lípidos y los vecinos se mueven en conjunto, formando racimos y patrones de flujo correlacionados que afectan las funciones de la membrana.

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Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells
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Last Updated: Jul 9, 2026

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
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Fluorescence Recovery after Merging a Droplet to Measure the Two-dimensional Diffusion of a Phospholipid Monolayer
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Fluorescence Recovery after Merging a Droplet to Measure the Two-dimensional Diffusion of a Phospholipid Monolayer

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Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells
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Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells

Published on: November 12, 2020

Área de la Ciencia:

  • La biofísica es la biofísica.
  • Biología celular Biología celular.
  • Biología computacional Biología computacional.

Sus antecedentes:

  • La dinámica de la membrana celular, incluida la difusión de lípidos, carece de modelos completos.
  • Comprender estas dinámicas es crucial para varios procesos biológicos.

Objetivo del estudio:

  • Para dilucidar el mecanismo de difusión de lípidos en las membranas celulares.
  • Para investigar el movimiento colectivo y las correlaciones espaciales de los lípidos.

Principales métodos:

  • Se emplearon simulaciones de dinámica molecular a escala atómica.
  • El análisis se centró en las trayectorias de los lípidos y las interacciones entre vecinos.

Principales resultados:

  • Se identificó un nuevo mecanismo concertado para la difusión de lípidos, donde los lípidos se mueven con sus vecinos más cercanos en grupos.
  • Los movimientos de los lípidos están correlacionados a lo largo de decenas de nanómetros, generando patrones de flujo bidimensionales dentro de la mono capa de la membrana.

Conclusiones:

  • Los hallazgos sugieren un nuevo modelo para la difusión lipídica, desafiando los conocimientos previos.
  • Estos patrones de flujo correlacionados tienen implicaciones significativas para la formación del dominio de la membrana, la función de las proteínas y las interacciones farmacológicas con las membranas.