Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
Amplifying Signals via Second Messengers01:15

Amplifying Signals via Second Messengers

Many receptor binding ligands are hydrophilic; they do not cross the cell membrane but bind to cell-surface receptors. Thus, their message must be relayed by second messengers present in the cell cytoplasm. There are several second messenger pathways, each with its own way of relaying information. For example, the G protein-coupled receptors can activate both phosphoinositol and cyclic AMP (cAMP) second messenger pathways. The phosphoinositol pathway is active when the receptor induces...
Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Phenotypic CRISPR screens identify NLRX1 as an essential activator of the human mitochondrial permeability transition.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Periodic ER-plasma membrane junctions support long-range Ca<sup>2+</sup> signal integration in dendrites.

Cell·2024
Same author

Elucidating and Optimizing the Photochemical Mechanism of Coumarin-Caged Tertiary Amines.

Journal of the American Chemical Society·2024
Same author

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins.

eLife·2023
Same author

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins.

bioRxiv : the preprint server for biology·2022
Same author

A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility.

Cell·2022

Video Experimental Relacionado

Updated: Jul 7, 2026

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading (TED)
09:32

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading (TED)

Published on: May 7, 2013

La señalización del calcio.

David E Clapham1

  • 1Aldo R. Castañeda Professor of Cardiovascular Research, Professor of Neurobiology, Harvard Medical School, Howard Hughes Medical Institute, Enders 1309, Children's Hospital Boston, Boston, MA 02115, USA. dclapham@enders.tch.harvard.edu

Cell
|December 18, 2007
PubMed
Resumen
Este resumen es generado por máquina.

Los iones de calcio (Ca2+) son cruciales para las funciones celulares, influyendo en el comportamiento de las proteínas y los niveles intracelulares. Esta revisión explora la señalización de Ca2+, sus acciones localizadas y roles en procesos celulares como la apoptosis y la transcripción.

Más Videos Relacionados

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis
09:07

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis

Published on: February 18, 2020

Live Calcium Imaging of Virus-Infected Human Intestinal Organoid Monolayers Using Genetically Encoded Calcium Indicators
08:01

Live Calcium Imaging of Virus-Infected Human Intestinal Organoid Monolayers Using Genetically Encoded Calcium Indicators

Published on: January 19, 2024

Videos de Experimentos Relacionados

Last Updated: Jul 7, 2026

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading (TED)
09:32

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading (TED)

Published on: May 7, 2013

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis
09:07

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis

Published on: February 18, 2020

Live Calcium Imaging of Virus-Infected Human Intestinal Organoid Monolayers Using Genetically Encoded Calcium Indicators
08:01

Live Calcium Imaging of Virus-Infected Human Intestinal Organoid Monolayers Using Genetically Encoded Calcium Indicators

Published on: January 19, 2024

Área de la Ciencia:

  • Biología celular Biología celular.
  • La bioquímica es la bioquímica.
  • Fisiología Fisiología Fisiología.

Sus antecedentes:

  • Los iones de calcio (Ca2+) son mensajeros intracelulares ubicuos.
  • Ca2+ regula una gran variedad de procesos celulares.

Objetivo del estudio:

  • Revisar los principios fundamentales de la señalización de Ca2+.
  • Discutir los mecanismos que controlan la homeostasis del Ca2+ en el citoplasma y en los orgánulos.
  • Para resaltar la naturaleza localizada de la transducción de señales de Ca2+.

Principales métodos:

  • Revisión de la literatura sobre los principios de señalización de Ca2+.
  • Examen de la unión de Ca2+ a las proteínas.
  • Análisis de los sistemas de transporte y amortiguación de Ca2+.

Principales resultados:

  • La unión de Ca2+ induce cambios conformacionales en las proteínas, alterando su función.
  • La regulación estricta de los niveles intracelulares de Ca2+ es esencial para la señalización celular.
  • Las señales de Ca2+ a menudo están altamente localizadas, lo que permite respuestas celulares específicas.

Conclusiones:

  • Ca2+ actúa como un regulador crítico en diversas funciones celulares.
  • Comprender la señalización de Ca2+ es clave para comprender la excitabilidad celular, la secreción, la motilidad, la muerte celular programada y la expresión génica.