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Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections
Published on: October 31, 2017
Las fibrillas amiloides derivadas del semen mejoran drásticamente la infección por el VIH
Jan Münch1, Elke Rücker, Ludger Ständker
1Institute of Virology, University Clinic of Ulm, 89081 Ulm, Germany.
Cell
|December 18, 2007
Resumen
Los fragmentos que ocurren naturalmente en el semen, llamados SEVI (Semen-derived Enhancer of Virus Infection), forman fibrillas amiloides. Estas fibrillas mejoran significativamente la transmisión del VIH durante las relaciones sexuales, ofreciendo nuevos objetivos de prevención.
Área de la Ciencia:
- Virología Virología.
- La bioquímica es la bioquímica.
- Inmunología Inmunología.
Sus antecedentes:
- Las relaciones sexuales son el principal modo de transmisión del VIH.
- Los factores endógenos en el semen pueden influir en la eficiencia de la transmisión sexual del VIH.
Objetivo del estudio:
- Identificar los factores endógenos en el semen humano que mejoran la transmisión sexual del VIH.
- Investigar el mecanismo por el cual estos factores mejoran la infectividad viral.
Principales métodos:
- Cribado de una biblioteca de péptidos/proteínas derivados del semen humano.
- Caracterización de la formación de fibrillas amiloides por fragmentos de fosfatasa ácida prostática (PAP).
- Evaluación del efecto del SEVI en la infección por VIH de varios tipos de células y tejidos in vitro e in vivo.
Principales resultados:
- Los fragmentos naturales de la fosfatasa ácida prostática (PAP) forman las fibrillas amiloides (SEVI).
- SEVI captura los viriones del VIH y promueve su adherencia a las células diana, aumentando significativamente el título infeccioso.
- El SEVI amplifica la infección por VIH en las células T, los macrófagos, los tejidos amigdalares y en ratas transgénicas.
Conclusiones:
- Los fragmentos de PAP amiloidogénico (SEVI) son abundantes en el líquido seminal y mejoran la infección por VIH.
- El SEVI juega un papel crucial en la mejora de la transmisión sexual del VIH a través del semen.
- SEVI representa un nuevo objetivo potencial para las estrategias de prevención del VIH.
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