Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

The Synapse02:47

The Synapse

Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Roles for Phosphatase PP4 in Rhythmicity and Compensation in the Neurospora Circadian System.

bioRxiv : the preprint server for biology·2026
Same author

A Screen To Identify Protein Phosphatases with Roles in Circadian Period, Temperature Compensation and Output in the <i>Neurospora</i> Circadian Clock.

bioRxiv : the preprint server for biology·2026
Same author

Electrical stimulation precisely reproduces naturalistic spiking activity in complete and intermixed neural populations in the primate retina.

bioRxiv : the preprint server for biology·2026
Same author

Population decoding of sound source location by receptive field neurons in the mouse superior colliculus.

bioRxiv : the preprint server for biology·2026
Same author

Leveraging current steering and the biophysics of spike generation for cellular-resolution electrical stimulation of neurons.

Cell reports·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026
Same journal

Structural basis for host membrane binding and remodeling by invading malaria parasites.

Cell·2026
Same journal

Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning.

Cell·2026
Same journal

Arc mediates intercellular tau transmission via extracellular vesicles.

Cell·2026
Same journal

Geometric constraints on the architecture of mammalian cortical connectomes.

Cell·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jun 19, 2026

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient
08:06

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient

Published on: September 3, 2014

La cascada clásica del complemento media en la eliminación de las sinapsis del SNC.

Beth Stevens1, Nicola J Allen, Luis E Vazquez

  • 1Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA. beths@standfordmedalumni.org

Cell
|December 18, 2007
PubMed
Resumen
Este resumen es generado por máquina.

La proteína del complemento C1q marca las sinapsis no deseadas para su eliminación durante el desarrollo neuronal. La reactivación aberrante de C1q en la retina adulta sugiere un papel en enfermedades neurodegenerativas como el glaucoma.

Más Videos Relacionados

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
10:05

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

Published on: March 18, 2021

Videos de Experimentos Relacionados

Last Updated: Jun 19, 2026

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient
08:06

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient

Published on: September 3, 2014

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
10:05

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

Published on: March 18, 2021

Área de la Ciencia:

  • La neurociencia es la neurociencia.
  • Inmunología Inmunología.
  • Biología del desarrollo Biología del desarrollo.

Sus antecedentes:

  • Los circuitos neuronales maduros requieren eliminar las conexiones sinápticas innecesarias durante el desarrollo.
  • El sistema del complemento, iniciado por C1q, juega un papel en las respuestas inmunes.

Objetivo del estudio:

  • Investigar el papel de C1q en la poda sináptica durante el desarrollo neuronal.
  • Explorar la participación potencial de C1q en enfermedades neurodegenerativas.

Principales métodos:

  • Estudió la expresión de C1q en las neuronas posnatales y su localización en las sinapsis.
  • Se utilizaron ratones con deficiencia de C1q y C3 para evaluar la eliminación de sinapsis.
  • Examinó la expresión de C1q en un modelo de ratón adulto de glaucoma.

Principales resultados:

  • Las neuronas posnatales expresan C1q, que se localiza en las sinapsis.
  • Los ratones que carecían de C1q o C3 mostraron defectos significativos en la eliminación de sinapsis del sistema nervioso central.
  • C1q se regula hacia arriba y se reubica en las sinapsis de la retina adulta durante el glaucoma temprano.

Conclusiones:

  • La C1q neuronal marca las sinapsis para su eliminación durante el desarrollo.
  • La eliminación de la sinapsis mediada por el complemento puede reactivarse en condiciones neurodegenerativas como el glaucoma.