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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

Evolución de una estrategia sintética: síntesis total de (+/-) -welwitindolinona A isonitril

Sarah E Reisman1, Joseph M Ready, Matthew M Weiss

  • 1Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.

Journal of the American Chemical Society
|January 18, 2008
PubMed
Resumen

Los investigadores sintetizaron la welwitindolinona A isonitrile, un producto natural, mediante reacciones químicas estereoselectivas. Los pasos clave incluyeron una cicloadición de [2+2] ceteno y un reordenamiento de semipinacol para construir la estructura molecular compleja de manera eficiente.

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