Video Experimental Relacionado
Updated: Jul 7, 2026
07:44
Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
Inmunidad tumoral: respuesta del efector al tumor y papel del microambiente
Alberto Mantovani1, Pedro Romero, A Karolina Palucka
1Istituto Clinico Humanitas and Institute of Pathology, University of Milan, Milan, Italy.
Lancet (London, England)
|February 16, 2008
Resumen
La inflamación puede, paradójicamente, promover o combatir el cáncer. Las moléculas sintéticas imitan la invasión de patógenos para activar las células inmunes, desencadenando la destrucción de las células cancerosas y amplificando las respuestas anticancerígenas para los tumores establecidos.
Área de la Ciencia:
- Inmunología Inmunología.
- Oncología Oncología.
- Investigación del cáncer Investigación del cáncer.
Sus antecedentes:
- La inflamación juega un doble papel en el cáncer, promoviendo la oncogénesis y, a veces, el rechazo del cáncer.
- El cambio de la inflamación procancerosa a la anticancerosa imita las respuestas de la infección del patógeno.
- Los cánceres a menudo carecen de señales de peligro, lo que dificulta las respuestas inmunológicas efectivas.
Objetivo del estudio:
- Explorar los mecanismos detrás del doble papel de la inflamación en el cáncer.
- Investigar estrategias para convertir la inflamación procáncer en inmunidad contra el cáncer.
- Evaluar las moléculas sintéticas como inmunoterapias contra el cáncer.
Principales métodos:
- Analizando las observaciones clínicas y experimentales de la inflamación en el cáncer.
- Desarrollar moléculas sintéticas que imiten las señales de peligro de patógenos.
- Investigando la activación de las células dendríticas y las respuestas inmunes posteriores.
Principales resultados:
- Las moléculas sintéticas activan las células dendríticas, produciendo citoquinas que inducen la muerte celular del cáncer.
- Las células cancerosas moribundas proporcionan antígenos, lo que lleva a la activación de células T y B específicas de antígenos.
- Este proceso amplifica la respuesta inflamatoria contra el cáncer.
Conclusiones:
- Si bien los medicamentos antiinflamatorios pueden prevenir algunos tipos de cáncer, la inmunización activa combinada con la activación del microambiente tumoral es prometedora para el tratamiento de cánceres establecidos.
- Las moléculas sintéticas pueden redirigir la inflamación hacia la destrucción del cáncer.
- Aprovechar las respuestas inmunes a través de la activación dirigida es una estrategia clave para el tratamiento del cáncer.
Videos de Conceptos Relacionados
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
01:27Cytotoxic T Cells-mediated Immune Response
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
01:40Cell-mediated Immune Responses
Overview
01:28Inflammatory Response
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...