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La señalización de los fosfoinosítidos vincula la transferasa O-GlcNAc a la resistencia a la insulina

Xiaoyong Yang1, Pat P Ongusaha, Philip D Miles

  • 1Howard Hughes Medical Institute and Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

Nature
|February 22, 2008
PubMed
Resumen

La enzima O-GlcNAc transferasa (OGT) se une a la membrana celular en respuesta a la insulina, modificando la vía de señalización de la insulina. Esta modificación de O-GlcNAc contribuye a la resistencia a la insulina y la diabetes tipo 2.

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