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Cortar a través de reinos: regeneración en plantas y animales

Kenneth D Birnbaum¹, Alejandro Sánchez Alvarado

¹Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY 10003, USA. ken.birnbaum@nyu.edu

|February 26, 2008

Resumen

Los organismos sobreviven a los daños usando células madre, pero si la regeneración utiliza el desarrollo embrionario o patrones genéticos únicos sigue sin estar claro en animales y plantas.

Área de la Ciencia:

Biología regenerativa Biología regenerativa.
Biología del desarrollo Biología del desarrollo.
Biología Comparada y Biología Comparada.

Sus antecedentes:

Los organismos multicelulares se enfrentan a constantes desafíos de supervivencia por el desgaste, las lesiones y las enfermedades.
El daño tisular es un problema común tanto en animales como en plantas.
Los organismos emplean el mantenimiento o la inducción de células madre para sobrevivir a los insultos.

Objetivo del estudio:

Explorar los mecanismos subyacentes a la regeneración de tejidos en organismos multicelulares.
Investigar el papel de las células madre en la supervivencia al desgaste fisiológico y la lesión.
Para determinar si la regeneración recapitula el desarrollo embrionario o utiliza mecanismos de patrones distintos.

Principales métodos:

Análisis comparativo de las estrategias regenerativas en animales y plantas.
Examen de los patrones de expresión génica durante la regeneración.
Revisión de la literatura existente sobre biología de células madre y genética del desarrollo.

Principales resultados:

Tanto los animales como las plantas utilizan estrategias basadas en células madre para la regeneración.
Los mecanismos de remodelación en la regeneración a menudo implican la redistribución de los genes embrionarios.
La naturaleza precisa de los circuitos de patrones en la regeneración todavía está bajo investigación.

Conclusiones:

La regeneración basada en células madre es una estrategia conservada en todos los reinos.
Los mecanismos moleculares precisos que impulsan la regeneración, ya sean embrionarios o únicos, requieren una mayor aclaración.
Comprender la regeneración es clave para abordar la reparación y el envejecimiento de los tejidos.

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