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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Los catalizadores de eliminación de Kemp por diseño computacional de enzimas

Daniela Röthlisberger1, Olga Khersonsky, Andrew M Wollacott

  • 1Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.

Nature
|March 21, 2008
PubMed
Resumen

Los investigadores diseñaron de forma computacional nuevas enzimas para catalizar reacciones no catalizadas previamente por biocatalizadores naturales. Este avance en la ingeniería de proteínas logró mejoras significativas en la tasa, lo que demuestra un nuevo y poderoso enfoque para crear enzimas personalizadas.

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