Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the timing and level of...
Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
Duplication of Chromatin Structure02:05

Duplication of Chromatin Structure

The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...
Nucleosome Remodeling02:54

Nucleosome Remodeling

Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Genome Editing Technologies for Cancer Therapy.

Current gene therapy·2026
Same author

Patient-derived organoid xenografts reveal the multifaceted role of the lncRNA <i>MALAT1</i> in breast cancer progression.

bioRxiv : the preprint server for biology·2026
Same author

A sub-set of guanine- and cytosine-rich genes are actively transcribed at the nuclear lamin B1 region.

Cellular and molecular life sciences : CMLS·2026
Same author

Longitudinal tracking of <i>MALAT1</i> level over a breast cancer patient's course of treatment and disease progression.

Molecular therapy. Oncology·2025
Same author

Loss of BPTF restores estrogen response and suppresses metastasis of mammary tumors.

Nature communications·2025
Same author

On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions.

bioRxiv : the preprint server for biology·2025

Video Experimental Relacionado

Updated: Jul 6, 2026

Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates
09:13

Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates

Published on: May 12, 2023

Dinámica de la cromatina y posicionamiento génico.

R Ileng Kumaran1, Rajika Thakar, David L Spector

  • 1Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA.

Cell
|March 25, 2008
PubMed
Resumen
Este resumen es generado por máquina.

El núcleo celular organiza los genes de manera dinámica. La actina y la miosina influyen en el movimiento y la expresión génica, afectando la organización y la actividad nuclear.

Más Videos Relacionados

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Chromatin Immunoprecipitation (ChIP) in Mouse T-cell Lines
11:39

Chromatin Immunoprecipitation (ChIP) in Mouse T-cell Lines

Published on: June 17, 2017

Videos de Experimentos Relacionados

Last Updated: Jul 6, 2026

Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates
09:13

Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates

Published on: May 12, 2023

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Chromatin Immunoprecipitation (ChIP) in Mouse T-cell Lines
11:39

Chromatin Immunoprecipitation (ChIP) in Mouse T-cell Lines

Published on: June 17, 2017

Área de la Ciencia:

  • Biología celular Biología celular.
  • Genética La genética.
  • Biología Molecular Biología Molecular

Sus antecedentes:

  • El núcleo celular de los mamíferos regula la expresión génica a través de la organización del genoma y las interacciones de proteínas.
  • La dinámica genética y las interacciones intercromosómicas son áreas clave de investigación.
  • Los roles de la actina y la miosina en la dinámica de la cromatina son cada vez más reconocidos.

Objetivo del estudio:

  • Revisar el conocimiento actual de la dinámica del genoma interfásico.
  • Para discutir el impacto de la dinámica del genoma en la organización nuclear.
  • Explorar la relación entre la dinámica del genoma y la actividad génica.

Principales métodos:

  • Revisión de la literatura de investigaciones recientes.
  • Discusión de los hallazgos experimentales sobre la dinámica de la cromatina.
  • Síntesis de datos sobre la organización nuclear y la regulación génica.

Principales resultados:

  • Los genes específicos exhiben un alto dinamismo dentro del núcleo.
  • La actina y la miosina están implicadas en la regulación del movimiento de la cromatina.
  • La organización del genoma influye significativamente en la expresión génica.

Conclusiones:

  • Comprender la dinámica del genoma es crucial para comprender la organización nuclear.
  • La actina y la miosina juegan un papel importante en la regulación de los genes.
  • La dinámica del genoma interfásico afecta la actividad genética general y la función nuclear.