La activación mediada por fosfolemas de Na/K-ATPasa limita [Na]i y el estado inotrópico durante la estimulación

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Measuring Cation Transport by Na,K- and H,K-ATPase in Xenopus Oocytes by Atomic Absorption Spectrophotometry: An Alternative to Radioisotope Assays
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Measuring Cation Transport by Na,K- and H,K-ATPase in Xenopus Oocytes by Atomic Absorption Spectrophotometry: An Alternative to Radioisotope Assays

Published on: February 19, 2013

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Sanda Despa1, Amy L Tucker, Donald M Bers

  • 1Department of Physiology, Loyola University Chicago, Maywood, Ill, USA.

Circulation
|March 26, 2008
PubMed
Resumen

La fosforilación de Phospholemman (PLM) estimula la Na/K-ATPasa cardíaca (NKA), atemperando los aumentos de sodio y calcio intracelulares durante la activación simpática. Esto limita la contractilidad y las arritmias en el corazón de los ratones.

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