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El complejo de proteínas de la envoltura de la membrana precursora del flavivirus: estructura y maduración

Long Li1, Shee-Mei Lok, I-Mei Yu

  • 1Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.

Science (New York, N.Y.)
|March 29, 2008
PubMed
Resumen

Los flavivirus maduran a través de la escisión de la proteína de la membrana precursora (prM), convirtiendo los virus inertes en partículas infecciosas. Este estudio revela la estructura heterodímera del virus del dengue prM-E, lo que explica la maduración y la inhibición de la fusión de las células huésped.

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