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Updated: Jul 6, 2026

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices
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La oxidación de M35 induce cambios estructurales y dinámicos similares a los de Abeta40 en Abeta42

Yilin Yan1, Scott A McCallum, Chunyu Wang

  • 1Biology Department, Center for Biotechnology and Interdisciplinary Studies, Rensselear Polytechnic Institute, Troy, New York 12180, USA.

Journal of the American Chemical Society
|April 2, 2008
PubMed
Resumen

La oxidación de la metionina 35 (M35) en beta-amiloide (Abeta) ralentiza la agregación y reduce la toxicidad. Esta oxidación hace que Abeta42 adopte cambios estructurales similares a los de Abeta40, lo que explica su disminución de los efectos nocivos.

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