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Un polimorfismo dentro del gen G6PC2 está asociado con los niveles de glucosa plasmática en ayunas
Nabila Bouatia-Naji1, Ghislain Rocheleau, Leentje Van Lommel
1CNRS UMR 8090 Institute of Biology, Pasteur Institute of Lille and Lille 2 Droit et Santé University, 59019 Lille, France.
Science (New York, N.Y.)
|May 3, 2008
Resumen
Una variante genética (rs560887) en el gen G6PC2 influye en los niveles de glucosa plasmática en ayunas y la función de las células beta pancreáticas. Este hallazgo puede explicar las variaciones en la regulación de la glucosa, pero no está relacionado con el riesgo de diabetes tipo 2.
Área de la Ciencia:
- Genética La genética.
- El metabolismo es el metabolismo.
- Endocrinología Endocrinología.
Sus antecedentes:
- Los niveles de glucosa plasmática en ayunas (FPG) dentro del rango normal aún pueden indicar un mayor riesgo de mortalidad.
- Las variaciones interindividuales en FPG requieren la identificación de los factores genéticos que contribuyen.
Objetivo del estudio:
- Identificar los determinantes genéticos de la variación interindividual en la glucosa plasmática en ayunas (GFP).
- Investigar la asociación de los polimorfismos de un solo nucleótido (SNPs) con los niveles de FPG en individuos normoglucémicos.
Principales métodos:
- El estudio de asociación de todo el genoma (GWAS) probó 392,935 SNPs en 654 participantes normoglucémicos.
- Replicación del SNP asociado superior (rs560887) en una cohorte independiente de 9353 participantes.
- Análisis de la asociación de SNP rs560887 con FPG y la función de las células beta pancreáticas (Homa-B).
Principales resultados:
- SNP rs560887, localizado en el gen G6PC2, mostró una fuerte asociación con FPG (P = 4 x 10(-23)).
- Este SNP también se asoció significativamente con la función de las células beta pancreáticas (P = 3 x 10−13).
- No se encontró ninguna asociación entre SNP rs560887 y el riesgo de diabetes tipo 2.
Conclusiones:
- El gen G6PC2, que codifica IGRP, juega un papel en la regulación de los niveles de glucosa plasmática en ayunas.
- SNP rs560887 puede influir en la FPG al modular la secreción de insulina estimulada por glucosa en las células beta pancreáticas.
- Investigaciones adicionales sobre la función de G6PC2 podrían proporcionar información sobre la homeostasis de la glucosa.
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