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Published on: August 18, 2017
Estereoquímica de los anestésicos inhalados: resolución óptica del halotano, el enflurano y el isoflurano
J Meinwald1, W R Thompson, D L Pearson
1Department of Chemistry, Cornell University, Ithaca, NY 14853-1301.
Science (New York, N.Y.)
|February 1, 1991
Resumen
Los investigadores desarrollaron un método para separar los enantiómeros de los anestésicos de inhalación comunes como el halotano, el enflurano y el isoflurano. Esto permite el análisis de formas anestésicas puras, no descritas anteriormente.
Área de la Ciencia:
- Química analítica Química analítica es la que
- Farmacología Farmacología.
- Química orgánica es la química orgánica.
Sus antecedentes:
- El halotano, el enflurano y el isoflurano son anestésicos de inhalación críticos.
- Estos anestésicos se administran actualmente como mezclas racémicas.
- Los enantiómeros puros y los métodos para su resolución no se han descrito previamente.
Objetivo del estudio:
- Desarrollar un método analítico para la resolución óptica de halotano, enflurano e isoflurano.
- Para permitir la determinación de las relaciones enantioméricas para estos anestésicos ampliamente utilizados.
Principales métodos:
- Se utilizó cromatografía gasosa capilar quiral.
- Empleado per-n-pentilado alfa-ciclodextrina (Lipodex A) para halotano y isoflurano resolución.
- Octacos usados ((6-O-metil-2,3-di-O-pentil) -gamma-ciclodextrina para la resolución del enflurano y el isoflurano.
Principales resultados:
- Se logró una resolución óptica completa del racémico halotano, enflurano e isoflurano.
- Demostró la capacidad para la determinación rápida y conveniente de las relaciones enantioméricas.
- Estableció fases estacionarias quirales efectivas para la separación de enantiómeros anestésicos.
Conclusiones:
- Se ha establecido un nuevo método analítico para la separación enantiomérica de los principales anestésicos de inhalación.
- Este método facilita la caracterización de enantiómeros puros previamente inaccesibles.
- La técnica desarrollada permite una determinación precisa de la relación enantiomérica en muestras de anestesia.
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