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Updated: Jul 5, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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Efectos dinámicos en las velocidades de reacción en una adición de Michael catalizada por isomerasa de calcón. Más

J Javier Ruiz-Pernía1, Iñaki Tuñón, Vicente Moliner

  • 1Departamento de Química Física, Universidad de Valencia, 46100 Burjassot, Spain.

Journal of the American Chemical Society
|May 16, 2008
PubMed
Resumen

Este estudio revela cómo la Chalcone Isomerase (CI) acelera las reacciones mediante la estabilización de las interacciones moleculares clave. Las simulaciones de eventos raros muestran que CI mejora la dinámica de adición de Michael en comparación con el agua, destacando la enzima.

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