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Síntesis total del ácido (+/-) -actinofílico
Connor L Martin1, Larry E Overman, Jason M Rohde
1Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, USA.
Journal of the American Chemical Society
|May 22, 2008
Resumen
Los investigadores informan de la primera síntesis total de ácido actinofílico. Los pasos clave involucraron el acoplamiento oxidativo y un reordenamiento aza-Cope-Mannich para construir el producto natural.
Área de la Ciencia:
- Química orgánica es la química orgánica.
- Síntesis de Productos Naturales.
Sus antecedentes:
- El ácido actinófilo es un producto natural complejo con un sistema de anillos único.
- Las rutas sintéticas anteriores para el ácido actinofílico carecían.
Objetivo del estudio:
- Para lograr la primera síntesis total de ácido (+/-) -actinofílico.
- Desarrollar una estrategia sintética eficiente y concisa.
Principales métodos:
- Utilizó un acoplamiento oxidativo intramolecular de cetona y enolados de éster malónico.
- Se empleó un reordenamiento aza-Cope-Mannich para ensamblar la estructura central.
- Sintetizó la molécula objetivo a partir del di-tert-butilamalonato.
Principales resultados:
- Se completó con éxito la primera síntesis total de ácido (+/-) -actinofílico.
- Logró un rendimiento general del 8%.
- La síntesis implicó una secuencia concisa con sólo siete intermediarios aislados.
Conclusiones:
- La ruta sintética desarrollada proporciona acceso al ácido actinofílico.
- Las reacciones clave, el acoplamiento oxidativo y el reordenamiento aza-Cope-Mannich, son efectivas para construir la compleja arquitectura del producto natural.
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