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Asociación entre la circulación de lipoproteínas oxidadas de baja densidad y la incidencia del síndrome metabólico
Paul Holvoet1, Duk-Hee Lee, Michael Steffes
1Atherosclerosis and Metabolism Unit, Katholieke Universiteit Leuven, Belgium.
JAMA
|May 22, 2008
Resumen
Los niveles más altos de lipoproteína oxidada de baja densidad (LDL) están relacionados con un mayor riesgo de desarrollar síndrome metabólico en adultos. Este hallazgo destaca el LDL oxidado como un biomarcador potencial para la incidencia del síndrome metabólico.
Área de la Ciencia:
- Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular
- Epidemiología de la Enfermedad Metabólica.
- El metabolismo de los lípidos.
Sus antecedentes:
- Los estudios experimentales sugieren un vínculo entre la lipoproteína oxidada de baja densidad (LDL) y el síndrome metabólico.
- Esta hipótesis, sin embargo, permaneció sin probar en poblaciones humanas antes de este estudio.
Objetivo del estudio:
- Investigar la asociación entre el LDL oxidado y la incidencia del síndrome metabólico en una comunidad en general.
- Determinar si el LDL oxidado es un factor de riesgo independiente para el desarrollo del síndrome metabólico.
Principales métodos:
- Se utilizaron datos del estudio de Desarrollo del Riesgo de la Arteria Coronaria en Adultos Jóvenes (CARDIA), una cohorte observacional prospectiva basada en la población.
- Se incluyeron 1889 participantes (de 18 a 30 años al inicio del estudio) evaluados en los años 15 y 20.
- Se midió el LDL oxidado utilizando un ensayo de inmunosorbente vinculado a enzimas y se definió el síndrome metabólico según los criterios del Panel de Tratamiento de Adultos III.
Principales resultados:
- El 12,9% de los participantes desarrolló el síndrome metabólico incidente en el año 20.
- Los quintiles más altos de LDL oxidado se asociaron significativamente con un aumento de las probabilidades de síndrome metabólico incidente (OR de entre 2,1 y 3,5).
- La LDL oxidada también se asoció con una mayor incidencia de obesidad abdominal, glucosa alta en ayunas y triglicéridos altos, independientemente de los niveles tradicionales de colesterol LDL.
Conclusiones:
- Las concentraciones elevadas de LDL oxidado están asociadas con una mayor incidencia de síndrome metabólico.
- Los hallazgos indican que el LDL oxidado puede ser un contribuyente significativo al desarrollo del síndrome metabólico y sus componentes clave.
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