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Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
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Published on: June 26, 2018

Disposición antiparalela de las hélices de la alfa-sinucleína ligada a las vesículas

Malte Drescher1, Gertjan Veldhuis, Bart D van Rooijen

  • 1Department of Molecular Physics, Leiden University, P.O. Box 9504, 2300 RA Leiden, The Netherlands.

Journal of the American Chemical Society
|June 3, 2008
PubMed
Resumen

La proteína alfa-sinucleína (alphaS) de la enfermedad de Parkinson adopta una estructura de hélice doblada y antiparalela cuando se une a las membranas. Este hallazgo aclara la conformación de la proteína en relación con las interacciones de la membrana.

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