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El supuesto Diels-Alderase macrophomate synthase es un eficiente aldolase

Jörg M Serafimov1, Dennis Gillingham, Simon Kuster

  • 1Laboratory of Organic Chemistry, ETH Zurich, CH-8093 Zurich, Switzerland.

Journal of the American Chemical Society
|June 3, 2008
PubMed
Resumen

La Macrophomate synthase (MPS) cataliza la adición de enolato de piruvato a los aldehídos, formando así los ácidos gamma-hidroxi-alfa-cetoácidos. Esto sugiere que una vía de Michael-aldol puede reemplazar la reacción de Diels-Alder en la catálisis de MPS.

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