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La estructura cristalina de la opsina del receptor acoplado a la proteína G libre de ligandos y acoplado a la

Jung Hee Park1, Patrick Scheerer, Klaus Peter Hofmann

  • 1Institut für Medizinische Physik und Biophysik (CC2), Charité-Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany.

Nature
|June 20, 2008
PubMed
Resumen

Determinamos la estructura cristalina de la opsina libre de ligandos, revelando cambios estructurales significativos en comparación con la rodopsina. Estos cambios en la estructura del receptor acoplado a la proteína G (GPCR) crean aberturas para la unión a la retina, ofreciendo información sobre la activación del GPCR.

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