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Censura del desarrollo de células B autorreactivas por el receptor de células pre-B
Rebecca A Keenan1, Alessandra De Riva, Björn Corleis
1Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, UK.
Science (New York, N.Y.)
|June 21, 2008
Resumen
El receptor de células pre-B juega un papel crucial en la prevención del desarrollo de células B secretoras de autoanticuerpos. Los ratones que carecen de cadenas de luz sustitutas muestran un aumento de los autoanticuerpos, lo que indica una falla en este punto de control crítico de auto-tolerancia.
Área de la Ciencia:
- Inmunología Inmunología.
- La autoinmunidad es autoinmunidad.
- Desarrollo de células B en el desarrollo celular.
Sus antecedentes:
- El desarrollo de las células B implica una recombinación genética aleatoria, lo que lleva a una potencial auto-reactividad.
- Existen mecanismos para eliminar las células B autorreactivas y mantener la auto-tolerancia.
Objetivo del estudio:
- Investigar el papel del receptor de células pre-B en la selección negativa de las células B autorreactivas.
- Para determinar el impacto de la deficiencia de la cadena ligera de sustitución en la producción de autoanticuerpos.
Principales métodos:
- Se utilizaron ratones sustitutos con deficiencia de cadena ligera (SLC-/-) de ratones.
- Análisis de los niveles séricos de anticuerpos antinucleares (ANA).
- Populaciones de células B evaluadas y sus procesos de selección.
Principales resultados:
- Los ratones SLC-/- exhibieron niveles elevados de ANA.
- Las células Pre-B que expresan cadenas pesadas de autoanticuerpos escaparon de la selección negativa.
- Se encontraron células B maduras que secretan autoanticuerpos en la periferia de SLC-/- ratones.
Conclusiones:
- El receptor de células pre-B es esencial para censurar el desarrollo de ciertas células B secretoras de autoanticuerpos.
- La deficiencia en la vía del receptor de células pre-B contribuye a la autoinmunidad.
- Esta vía puede ser un factor significativo en las enfermedades autoinmunes multifactoriales.
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