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Cambio abrupto del patrón de variación diurna en el inicio del accidente cerebrovascular con transiciones al horario
Christian Foerch1, Horst-Werner Korf, Helmuth Steinmetz
1Department of Neurology, Goethe University, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany. foerch@em.uni-frankfurt.de
Circulation
|June 25, 2008
Resumen
Las transiciones del horario de verano (DST) cambian inmediatamente los tiempos de inicio del accidente cerebrovascular, lo que indica que factores externos como la actividad matutina influyen en los patrones diarios de accidente cerebrovascular. Esto desafía los ajustes rápidos del reloj circadiano interno como la causa principal.
Área de la Ciencia:
- Neurología Neurología.
- Cronobiología cronobiología.
- Salud Pública La salud pública.
Sus antecedentes:
- El inicio del accidente cerebrovascular exhibe variación diurna, con un pico en la mañana.
- Los ritmos biológicos internos y los factores externos como la actividad física son influencias potenciales.
- Las transiciones al horario de verano (DST) ofrecen una oportunidad única para estudiar los impactos externos del reloj.
Objetivo del estudio:
- Investigar cómo los desplazamientos del reloj externo, específicamente las transiciones al horario de verano (DST), afectan el patrón diurno de inicio del accidente cerebrovascular.
- Evaluar el papel de los factores exógenos en la variación diaria de la ocurrencia de ictus.
Principales métodos:
- Análisis de un prospectivo registro de accidentes cerebrovasculares en Alemania (44.251 pacientes, 2000-2005).
- Los tiempos de inicio del accidente cerebrovascular se estandarizaron a una línea de tiempo uniforme durante los períodos de DST.
- Comparación de los patrones de inicio del ictus antes y después de las transiciones del DST (primavera y otoño).
Principales resultados:
- Las transiciones DST causaron un cambio inmediato en los tiempos de inicio del accidente cerebrovascular dentro de la primera semana.
- Se observaron cambios de -60 minutos (primavera) y +60 minutos (otoño) en los percentiles de inicio del accidente cerebrovascular.
- Los cambios significativos fueron evidentes ya en el primer y segundo día después de la transición.
Conclusiones:
- Los cambios externos del reloj, como las transiciones al horario de verano, están directamente relacionados con los cambios inmediatos en el tiempo de inicio del accidente cerebrovascular.
- Esto apoya la hipótesis de que los factores exógenos relacionados con el despertar juegan un papel significativo en la variación diurna del ictus.
- Es poco probable que el rápido arrastre del reloj circadiano humano explique estos cambios inmediatos.
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