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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Published on: February 7, 2019

Síntesis total enantioselectiva y selectiva de la licopodina

Hua Yang1, Rich G Carter, Lev N Zakharov

  • 1Department of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, Oregon 97331, USA.

Journal of the American Chemical Society
|June 28, 2008
PubMed
Resumen

Los investigadores lograron la primera síntesis total enantioselectiva de la licopodina. Esto implicó una ciclización organocatalizada diastereoselectiva y una ciclización en tándem de desplazamiento de sulfonilo / ciclización de Mannich para construir la molécula compleja.

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