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Videos de Conceptos Relacionados

RNA Structure01:19

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...

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Nanomanipulation of Single RNA Molecules by Optical Tweezers
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Published on: August 20, 2014

Conocimiento estructural de los intermediarios de plegado de la horquilla del ARN.

Gregory R Bowman1, Xuhui Huang, Yuan Yao

  • 1Biophysics Program, Stanford University, Stanford, California 94305, USA.

Journal of the American Chemical Society
|July 3, 2008
PubMed
Resumen

Las horquillas de ARN, cruciales para la función molecular, pueden plegarse a través de múltiples estados. Las simulaciones revelan estructuras intermedias, lo que sugiere que el plegamiento no es un simple reverso del despliegue, una característica común en los procesos biomoleculares.

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Área de la Ciencia:

  • Biología Molecular Biología Molecular
  • La biofísica es la biofísica.
  • Química computacional es la química computacional.

Sus antecedentes:

  • Las horquillas de ARN son estructuras secundarias fundamentales en las moléculas de ARN.
  • El mecanismo de plegado de las horquillas de ARN (dos estados frente a varios estados) sigue siendo objeto de investigación.
  • Comprender el plegamiento de la horquilla es clave para comprender las relaciones estructura-función del ARN.

Objetivo del estudio:

  • Para investigar la trayectoria de plegado de una pequeña horquilla de tetraloop.
  • Para determinar si el plegado de la horquilla sigue un modelo de dos estados o de varios estados.
  • Para identificar posibles estructuras intermedias durante el proceso de plegado.

Principales métodos:

  • Utilizó una versión en serie de la dinámica molecular de intercambio de réplicas (REMD).
  • Empleó un entorno de computación distribuida para mejorar las capacidades de simulación.
  • Se analizaron las trayectorias de simulación para identificar los intermediarios de plegado.

Principales resultados:

  • Identificó varias estructuras intermedias durante el plegado de la horquilla.
  • Estos productos intermedios son consistentes con los datos experimentales existentes.
  • Se observó que la trayectoria de plegado no es una simple inversión del despliegue a alta temperatura.

Conclusiones:

  • Es probable que el plegamiento de la horquilla de ARN proceda a través de múltiples estados, que involucran intermedios transitorios.
  • La trayectoria plegable puede diferir significativamente de la trayectoria desplegable.
  • Este complejo mecanismo de plegado podría ser una característica general de los procesos de plegado biomolecular.