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Export of Misfolded Proteins out of the ER01:32

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After folding, the ER assesses the quality of secretory and membrane proteins. The correctly folded proteins are cleared by the calnexin cycle for transport to their final destination, while misfolded proteins are held back in the ER lumen. The ER chaperones attempt to unfold and refold the misfolded proteins but sometimes fail to achieve the correct native conformation. Such terminally misfolded proteins are then exported to the cytosol by ER-associated degradation or ERAD pathway for...
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ATP-binding cassette or ABC transporter is the largest superfamily of integral membrane proteins. The transporters have transmembrane-binding domains (TMDs) and nucleotide-binding domains (NBDs). The TMDs are specific to their substrates, whereas the NBDs are similar to engines that complete ATP hydrolysis to complete the substrate transport. They can be full transporters consisting of two TMDs and NBDs, half transporters with one TMD and NBD, while some encoded with a single TMD or NBD are...
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Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

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10:38

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Published on: July 17, 2014

Desconstruyendo la exportación de proteínas de la malaria.

Serge Bonnefoy1, Robert Ménard

  • 1Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, 75724 Paris Cedex 15, France.

Cell
|July 11, 2008
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores examinaron los genes del parásito de la malaria esenciales para la virulencia. Muchos más genes de lo previsto son cruciales para la supervivencia de Plasmodium falciparum in vitro.

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Área de la Ciencia:

  • Malariología Malariología.
  • La parasitología molecular.
  • Biología celular Biología celular.

Sus antecedentes:

  • El parásito de la malaria Plasmodium falciparum causa enfermedades severas.
  • La virulencia de los parásitos depende de las proteínas exportadas a la superficie de los glóbulos rojos infectados.

Objetivo del estudio:

  • Identificar genes involucrados en la exportación y el tráfico de proteínas de Plasmodium falciparum.
  • Para determinar la esencialidad de estos genes para la supervivencia de los parásitos.

Principales métodos:

  • Prueba genética sistemática de los genes de Plasmodium falciparum.
  • Pruebas in vitro para evaluar la supervivencia de los parásitos.

Principales resultados:

  • Identificó un número significativo de genes esenciales no reconocidos previamente para la exportación de proteínas de parásitos.
  • Demostró que muchos más genes de lo esperado son críticos para la supervivencia de Plasmodium falciparum.

Conclusiones:

  • La maquinaria de exportación y tráfico de Plasmodium falciparum es más compleja de lo que se pensaba.
  • Estos hallazgos destacan nuevos objetivos para el desarrollo de fármacos antipalúdicos.