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El origen y las funciones fisiológicas de la inflamación

Ruslan Medzhitov¹

¹Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, TAC S-669, 300 Cedar Street, New Haven, Connecticut 06510, USA. ruslan.medzhitov@yale.edu

|July 25, 2008

Resumen

La parainflamación es una respuesta adaptativa recientemente identificada al estrés tisular, distinta de la inflamación clásica. Este proceso impulsado por los macrófagos puede ser la base de las enfermedades crónicas relacionadas con las condiciones de salud humana moderna.

Área de la Ciencia:

Fisiología Fisiología Fisiología.
Patología Patología Patología.
Inmunología Inmunología.

Sus antecedentes:

La inflamación es crucial en los procesos fisiológicos y patológicos.
Si bien se comprende la inflamación patológica, sus funciones fisiológicas siguen siendo en gran medida desconocidas.
La inflamación clásica, desencadenada por una infección o lesión, implica el reclutamiento de leucocitos y proteínas plasmáticas.

Objetivo del estudio:

Introducir y definir la parainflamación como una respuesta adaptativa distinta.
Para diferenciar la parainflamación de la inflamación clásica.
Explorar el papel de la parainflamación en las enfermedades crónicas.

Principales métodos:

Desarrollo del marco conceptual. desarrollo del marco conceptual.
Revisión y síntesis de la literatura.
Análisis comparativo de las respuestas inflamatorias.

Principales resultados:

La parainflamación es una respuesta adaptativa al estrés o mal funcionamiento de los tejidos.
Esta respuesta involucra principalmente a los macrófagos residentes en el tejido.
La parainflamación representa un estado intermedio entre la homeostasis y la inflamación clásica.

Conclusiones:

La parainflamación es un proceso fisiológico crítico.
Es probable que sea responsable de las condiciones inflamatorias crónicas asociadas con las enfermedades modernas.
Se justifica una mayor investigación sobre la parainflamación para comprender sus implicaciones para la salud humana.

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