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Los enterococos resistentes a la vancomicina explotan los déficits inmunológicos innatos inducidos por los

Katharina Brandl1, George Plitas, Coralia N Mihu

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Resumen

Los antibióticos de amplio espectro reducen el RegIIIgamma, una proteína inmune clave, lo que permite infecciones peligrosas de ERV. La restauración de RegIIIgamma a través de la estimulación del receptor Toll-like ofrece una forma de combatir las bacterias resistentes a los antibióticos.

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Área de la Ciencia:

  • Microbiología Microbiología.
  • Inmunología Inmunología.
  • Gastroenterología y Gastroenterología.

Sus antecedentes:

  • Las infecciones bacterianas resistentes a los antibióticos, como el enterococo resistente a la vancomicina (ERV), son desafíos significativos para la atención médica.
  • Los mecanismos por los cuales el uso de antibióticos promueve estas infecciones no se comprenden completamente.

Objetivo del estudio:

  • Para investigar el impacto del tratamiento con antibióticos en las defensas inmunitarias intestinales contra las bacterias resistentes a los antibióticos.
  • Identificar los mecanismos moleculares que vinculan la terapia con antibióticos con el aumento de la susceptibilidad al ERV.

Principales métodos:

  • Tratamiento antibiótico de ratones para evaluar cambios en la expresión génica intestinal.
  • Cuantificación de la colonización del enterococo resistente a la vancomicina (ERV) en el intestino.
  • Estimulación del receptor tipo Toll 4 (TLR4) con lipopolisacárido (LPS) para evaluar la respuesta inmune.

Principales resultados:

  • La terapia con antibióticos redujo significativamente la expresión intestinal de RegIIIgamma (Reg3g) en ratones.
  • La reducción de los niveles de RegIIIgamma se correlacionó con un aumento de la colonización de ERV.
  • La administración oral de lipopolisacáridos (LPS) restauró la expresión de RegIIIgamma y aumentó la resistencia a VRE.

Conclusiones:

  • La supresión inducida por antibióticos de RegIIIgamma compromete la inmunidad de la mucosa innata contra patógenos Gram-positivos como VRE.
  • Dirigirse a los receptores de tipo Toll presenta una estrategia potencial para restaurar la defensa de la mucosa y combatir las infecciones resistentes a los antibióticos.