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Las vías Wnt opuestas orientan la polaridad celular durante la organogénesis
Jennifer L Green1, Takao Inoue, Paul W Sternberg
1Howard Hughes Medical Institute/Division of Biology, California Institute of Technology, Mail Code 156-29, Pasadena, CA 91125, USA.
Cell
|August 30, 2008
Resumen
La polaridad del tejido depende de la integración de múltiples vías Wnt. La división celular asimétrica en el desarrollo de C. elegans vulva utiliza Wnts para orientar las células y establecer la polaridad de base a través de nuevos mecanismos de señalización.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Biología celular Biología celular.
- Genética La genética.
Sus antecedentes:
- La división celular asimétrica es crucial para la organización de los tejidos y órganos.
- En el desarrollo de la vulva de C. elegans, la simetría de imagen especular se logra mediante orientaciones de división opuestas de las células precursoras vulvales (VPC).
Objetivo del estudio:
- Caracterizar los mecanismos moleculares que rigen los patrones de división asimétrica de los VPC en C. elegans.
- Para aclarar cómo múltiples vías de señalización Wnt contribuyen a establecer la polaridad del tejido.
Principales métodos:
- Análisis de los componentes de señalización Wnt (MOM-2, LIN-44, EGL-20) y sus receptores (Fz/LIN-17, Ryk/LIN-18, CAM-1, VANG-1).
- Investigando la localización de la beta-catenina y la activación de la transcripción génica.
- Estudiar el establecimiento de la polaridad celular "terreno".
Principales resultados:
- Las Wnts MOM-2 y LIN-44, expresadas en el eje de simetría, orientan los VPC centralmente a través de las vías Fz/LIN-17 y Ryk/LIN-18.
- Se establece una polaridad uniforme de "tierra" mediante la señalización Wnt/EGL-20.
- EGL-20 utiliza una nueva vía que involucra a la tirosina quinasa del receptor Ror CAM-1 y el componente de polaridad de las células planas Van Gogh/VANG-1.
Conclusiones:
- La polaridad del tejido está determinada por la integración de distintas vías de señalización Wnt.
- Múltiples vías Wnt cooperan para controlar la orientación de la división celular y establecer la polaridad durante el desarrollo de la vulva.
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