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Updated: Jul 2, 2026

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
05:15

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

Evidencia de que el mecanismo de la fotoliasa (6-4) puede proceder a través de un intermediario de oxetano

Saâdia Asgatay1, Christian Petermann, Dominique Harakat

  • 1Université de Reims Champagne Ardenne, Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, UFR de Pharmacie, 51 rue Cognacq-Jay, 51096 Reims Cedex, France.

Journal of the American Chemical Society
|September 4, 2008
PubMed
Resumen

Los investigadores utilizaron un dimero de timina modificado (Tpm3T) para investigar la reparación del ADN. Descubrieron que la adición de agua a un intermediario de oxetano lo abre, proporcionando evidencia de la vía de reparación de la fotoliasa (6-4) que involucra intermediarios de oxetano.

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