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Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes
09:40

Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes

Published on: September 28, 2018

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El acoplamiento estructural de los dominios de SH2-cinasa enlaza el reconocimiento del sustrato Fes y Abl y la

Panagis Filippakopoulos1, Michael Kofler, Oliver Hantschel

  • 1Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK.

Cell
|September 9, 2008
PubMed
Resumen

El dominio SH2 de las tirosinacinasas Fes y Abl mejora la señalización al interactuar con el dominio de la quinasa. Esta integración estructural es crucial para la activación de la quinasa y el reconocimiento del sustrato en estas quinasas pro-oncogénicas.

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