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Updated: Jul 1, 2026

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
06:58

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Published on: October 18, 2024

La proteína asociada a la mucolipidosis tipo IV TRPML1 es un canal de liberación de hierro endolisosomal

Xian-Ping Dong1, Xiping Cheng, Eric Mills

  • 1The Department of Molecular, Cellular, and Developmental Biology, The University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, Michigan 48109, USA.

Nature
|September 17, 2008
PubMed
Resumen

La mucolipina de potencial receptor transitorio 1 (TRPML1) actúa como un canal Fe2+ en endosomas y lisosomas tardíos. Las mutaciones que afectan la función de TRPML1 contribuyen a los síntomas de la enfermedad de la mucolipidosis tipo IV al afectar el metabolismo del hierro.

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