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Reparación del ADN por el complejo MRN: romperlo para hacerlo

Roland Kanaar1, Claire Wyman

  • 1Department of Cell Biology and Genetics, Cancer Genomics Center, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands.

Cell
|October 16, 2008
PubMed
Resumen

La inestabilidad genómica en el trastorno similar a la telangiectasia de ataxia y el síndrome de ruptura de Nijmegen surge de la interrupción del complejo Mre11-Rad50-Nbs1. La actividad de la nucleasa de Mre11 es crucial para mantener la estabilidad del genoma de los mamíferos.

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