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Ranolazina para el tratamiento de la angina estable crónica.

David T Nash1, Stephen D Nash

  • 1Syracuse Preventive Cardiology, Syracuse, NY 13202, USA. Davidtnash@aol.com

Lancet (London, England)
|October 22, 2008
PubMed
Resumen

La ranolazina, un nuevo medicamento antianginal, trata eficazmente la angina de pecho crónica estable inhibiendo la entrada tardía de sodio. Este medicamento único mejora la tolerancia al ejercicio y reduce los síntomas de la angina, ofreciendo una adición segura a los regímenes de tratamiento existentes.

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Área de la Ciencia:

  • Cardiología Cardiología.
  • Farmacología Farmacología.

Sus antecedentes:

  • La angina de pecho estable crónica es una condición prevalente que requiere opciones de tratamiento efectivas.
  • Las terapias antianginales actuales tienen limitaciones, lo que requiere nuevos enfoques.

Objetivo del estudio:

  • Evaluar la eficacia y seguridad de la ranolazina como un nuevo fármaco antianginal.
  • Comprender el mecanismo de acción de la ranolazina en el tratamiento de la angina.

Principales métodos:

  • Administración de ranolazina en una formulación de liberación sostenida.
  • Revisión de tres ensayos aleatorizados que evalúan el impacto de la ranolazina en las pruebas de ejercicio y los episodios anginales.

Principales resultados:

  • La ranolazina demostró eficacia en el aumento de la tolerancia al ejercicio.
  • El medicamento fue eficaz en la reducción de los episodios anginales y el uso de trinitrato de glicerilo.
  • Los efectos secundarios identificados incluyen mareos, estreñimiento, náuseas y una posible prolongación del intervalo QT.

Conclusiones:

  • La ranolazina es un agente antianginal seguro y eficaz para la angina crónica estable.
  • Representa una valiosa adición a los regímenes de medicamentos múltiples para la gestión de casos complejos.