Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Crystal Field Theory - Octahedral Complexes02:58

Crystal Field Theory - Octahedral Complexes

Crystal Field Theory
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Complexation Equilibria: Overview01:23

Complexation Equilibria: Overview

Complexation reactions take place when dative or coordinate covalent bonds form between metal ions and ligands. The compounds formed in these reactions are called coordination compounds. The number of bonds formed between the metal ion and the ligands is called its coordination number. Generally, most metal ions in an aqueous solution are solvated by water molecules and thus exist as aqua complexes.
The equilibrium constant of the complexation reaction is represented as the formation constant...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Functional and structural basis of a hypermorphic TRPC3 variant.

Science advances·2026
Same author

Dynamic signature of activity-stability tradeoff in lactamase evolution.

Nature communications·2026
Same author

Alteration of the Lipid Bilayer Structure by Mg<sup>2</sup>.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Thermal Degradation Energy Landscapes of Fluorofentanyls: Probing the Mechanisms and Energetics of Bond Breaking.

The journal of physical chemistry. B·2025
Same author

Phosphates and Phosphorylated Amino Acids for the AMOEBA-HFC Polarizable Force Field.

Journal of chemical theory and computation·2025
Same author

The glutaminase activity of ASNS fuels glutamine metabolism in leukemia.

Haematologica·2025

Video Experimental Relacionado

Updated: Jun 28, 2026

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

Transiciones estructurales en la coordinación iónica impulsadas por cambios en la competencia para la unión de

Sameer Varma1, Susan B Rempe

  • 1Sandia National Laboratories, Albuquerque, New Mexico 87185, USA. svarma@sandia.gov

Journal of the American Chemical Society
|October 29, 2008
PubMed
Resumen

La comprensión de la partición iónica requiere considerar los efectos de solvación. La reducción de las penalizaciones de energía libre para la extracción de ligandos estabiliza una mayor coordinación iónica, crucial para las interacciones biomoleculares y la unión iónica.

Más Videos Relacionados

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
11:19

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels

Published on: July 4, 2016

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

Videos de Experimentos Relacionados

Last Updated: Jun 28, 2026

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
11:19

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels

Published on: July 4, 2016

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

Área de la Ciencia:

  • Química biofísica y bioquímica.
  • Química computacional es la química computacional.
  • Biología Estructural Biología estructural.

Sus antecedentes:

  • Los iones de sodio (Na+) y potasio (K+) en el agua adoptan estados de coordinación específicos.
  • Los iones a menudo pasan a estados con números de coordinación más altos en los sistemas biológicos, a pesar de un aparente costo de energía libre.

Objetivo del estudio:

  • Para aclarar el papel del entorno de solvación en la conducción de las transiciones de la estructura de coordinación iónica.
  • Comprender los factores energéticos que rigen la partición de iones en estados de coordinación más altos.

Principales métodos:

  • Teoría estadística de las soluciones.
  • Simulaciones químicas cuánticas de las simulaciones químicas cuánticas.
  • Simulaciones de mecánica clásica en las simulaciones.
  • La informática estructural es una informática estructural.

Principales resultados:

  • El entorno de solvación influye significativamente en las transiciones de coordinación iónica.
  • Las penalizaciones de energía libre para la extracción de ligandos de capas de solvación impactan las preferencias de coordinación iónica.
  • La reducción de estas sanciones mejora la estabilidad de las coordinaciones iónicas de orden superior y reduce los costos de particionamiento.
  • La reducción de las interacciones favorables de los ligandos con átomos no iónicos disminuye las penalizaciones y aumenta las preferencias de coordinación.

Conclusiones:

  • Las propiedades de la fase de disolución son los principales impulsores de las transiciones de la estructura de coordinación iónica.
  • La modulación de las interacciones ligando-ambiente puede alterar las preferencias de coordinación iónica, imitando los efectos de Hofmeister.
  • Los hallazgos son aplicables a otros iones e influenciados por la densidad del ligando, la química y la temperatura.