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Los triglicéridos no en ayunas y el riesgo de ictus isquémico en la población general
Jacob J Freiberg1, Anne Tybjaerg-Hansen, Jan Skov Jensen
1Department of Clinical Biochemistry, Herlev Hospital, DK-2730 Herlev, Denmark.
JAMA
|November 13, 2008
Resumen
Los triglicéridos elevados no en ayunas están relacionados con un mayor riesgo de accidente cerebrovascular isquémico. Este estudio encontró una clara asociación entre niveles más altos de triglicéridos y una mayor probabilidad de sufrir un accidente cerebrovascular.
Área de la Ciencia:
- Investigación cardiovascular Investigación cardiovascular Investigación cardiovascular Investigación cardiovascular Investigación cardiovascular
- Epidemiología La epidemiología.
- El metabolismo de los lípidos.
Sus antecedentes:
- Se debate la asociación entre los triglicéridos y el riesgo de accidente cerebrovascular isquémico.
- Los hallazgos recientes sugieren que los triglicéridos elevados no en ayunas, indicativos de lipoproteínas remanentes, se correlacionan con el riesgo de enfermedad cardíaca isquémica.
Objetivo del estudio:
- Investigar la hipótesis de que los niveles elevados de triglicéridos no en ayunas aumentan el riesgo de accidente cerebrovascular isquémico en la población general.
Principales métodos:
- Estudio prospectivo de cohorte basado en la población (Copenhagen City Heart Study) con más de 13.956 participantes seguidos para la incidencia de accidente cerebrovascular isquémico.
- Análisis transversal de 9.637 personas que examinaron los triglicéridos no en ayunas, el colesterol remanente y la prevalencia del accidente cerebrovascular.
Principales resultados:
- Una tendencia significativa (P < .001) mostró un aumento de la incidencia de accidente cerebrovascular isquémico con un aumento de los niveles de triglicéridos no en ayunas en hombres y mujeres.
- Las proporciones de riesgo de accidente cerebrovascular isquémico aumentaron sustancialmente con mayores concentraciones de triglicéridos, con riesgos absolutos a 10 años que oscilan entre el 1,9% y el 16,7% dependiendo de la edad y los niveles de triglicéridos.
- Los datos transversales revelaron niveles más altos de triglicéridos no en ayunas y de colesterol remanente en individuos con antecedentes de accidente cerebrovascular isquémico en comparación con los controles.
Conclusiones:
- Los niveles de triglicéridos no en ayunas se asocian significativamente con un mayor riesgo de accidente cerebrovascular isquémico en esta población de estudio.
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