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Updated: Jun 28, 2026

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions
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Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions

Published on: January 26, 2024

La polarización de las proteínas es fundamental para estabilizar los dominios AF-2 y helix-2' en la unión del ligando

C G Ji1, J Z H Zhang

  • 1Institute of Theoretical and Computational Chemistry, Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.

Journal of the American Chemical Society
|November 15, 2008
PubMed
Resumen

La polarización de las proteínas es crucial para estabilizar el receptor activado por el proliferador peroxisomático (PPAR-gamma) y su unión a agonistas como la rosiglitazona. Este estudio pone de relieve cómo la polarización preserva los enlaces esenciales de hidrógeno y la estructura de las proteínas, vitales para la función biológica.

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