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El complejo regulador de la dineína es necesario para la motilidad ciliar y la biogénesis de otolitos en el oído
Jessica R Colantonio1, Julien Vermot, David Wu
1Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095, USA.
Nature
|December 2, 2008
Resumen
La motilidad de los cilios es esencial para el ensamblaje de otolitos en los teleósteos. La interrupción de la función de los cilios con el complejo de dynein afecta la biogénesis y la localización de los otolitos, revelando el flujo impulsado por los cilios.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Biología Sensorial Biología Sensorial
- La biomineralización es la biomineralización.
Sus antecedentes:
- Los peces teleost dependen de los otolitos del oído interno para el equilibrio y la audición.
- La formación y colocación de otolitos se controlan con precisión durante el desarrollo.
- Los mecanismos que guían el ensamblaje de otolitos en las células ciliadas sensoriales siguen siendo en gran medida desconocidos.
Objetivo del estudio:
- Para investigar el papel de la motilidad de los cilios en el ensamblaje y la localización de otolitos.
- Para dilucidar los mecanismos subyacentes a la biomineralización del otolito en los teleósteos.
Principales métodos:
- Microscopía de video in vivo del desarrollo del oído interno teleost.
- Eliminación dirigida del complejo regulador de la dineína y las subunidades de dineína del brazo externo.
- Análisis de la motilidad de los cilios y la formación de otolitos.
Principales resultados:
- Los cilios móviles generan vórtices de fluidos que atraen a las partículas precursoras del otolito.
- La alteración de la motilidad de los cilios conduce a una biogénesis y localización defectuosas de los otolitos.
- El complejo regulador de la dineína es crucial para la función de los cilios de los vertebrados en este proceso.
Conclusiones:
- La motilidad de los cilios es necesaria para el ensamblaje y la localización normales de otolitos en los teleósteos.
- El flujo de fluidos impulsado por los cilios actúa como un factor epigenético clave en la biomineralización del otolito.
- Este estudio pone de relieve la importancia del complejo regulador de la dineína en el desarrollo de los vertebrados.
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